Forschung & Lehre
Timo Zippelius forscht seit über zehn Jahren zur Wirbelsäule und zum Bewegungsapparat. PubMed listet 68 Veröffentlichungen in Fachzeitschriften (Stand November 2026). Schwerpunkte sind Operationsentscheidungen und Infektionen an der Wirbelsäule, der Zusammenhang von Rückenmuskulatur, Knochenqualität und Haltung sowie die Behandlung des Knochenmarködems.
2026
Pitzen T, Drumm J, Zippelius T, Ruf M. Sports and Spondylolysis: Chances and Limits. Sportverletz Sportschaden. 2026 Jul 13.
https://pubmed.ncbi.nlm.nih.gov/42442709/
Ruf M, Tiripa IL, Pitzen T, Zippelius T, Jeszenszky D. Correction of sagittal balance within the iliosacral joints. Spine Deform. 2026 Sep;14(5):1935-1939.
https://pubmed.ncbi.nlm.nih.gov/42283945/
Verna B, Caffard T, Burkhard MD, …, Zippelius T, …, Hughes AP. Relationship between Preoperative Global Sagittal Alignment and Changes in Cervical Alignment Following Lumbar Pedicle Subtraction Osteotomy. Spine (Phila Pa 1976). 2026 Jul 1;51(13):910-922.
https://pubmed.ncbi.nlm.nih.gov/42044623/
Zippelius T, Caffard T, Matziolis G, …, Strube P. Vancomycin: a dura damaging friend of the spine surgeon? An experimental study. Eur Spine J. 2026 Oct;35(10):6308-6315.
https://pubmed.ncbi.nlm.nih.gov/41920347/
Mansour R, Pitzen T, Drumm J, …, Zippelius T, …, Ruf M. Spinal aneurysmal bone cysts in children: institutional chart review and recommendation for treatment. Eur Spine J. 2026 Aug;35(8):4905-4917.
https://pubmed.ncbi.nlm.nih.gov/41491133/
Caffard T, Arzani A, Verna B, …, Zippelius T, …, Hughes AP. Association Between Severity of Cervical Central Spinal Stenosis and Paraspinal Muscle Parameters in Patients Undergoing Anterior Cervical Discectomy and Fusion. Spine (Phila Pa 1976). 2026 Sep 15;51(18):1310-1318.
https://pubmed.ncbi.nlm.nih.gov/38605673/
2025
Malik HA, Kiebler A, Müller J, …, Zippelius T, …, Kocak T. Longitudinal analysis of radiological parameters after monosegmental lumbar instrumentation and posterior lumbar interbody fusion (PLIF) compared with transforaminal lumbar interbody fusion (TLIF). J Orthop. 2025 Jun 3;69:162-171.
https://pubmed.ncbi.nlm.nih.gov/40535833/
Caffard T, Verna B, Schönnagel L, …, Zippelius T, Hughes AP. Cervical Muscle Composition in Degenerative Dropped Head Syndrome: A Propensity Score Matching Study. Spine (Phila Pa 1976). 2025 Oct 1;50(19):1303-1312.
https://pubmed.ncbi.nlm.nih.gov/40509854/
Putzier M, Fussi J, Khakzad T, Lindemann C, Zippelius TK, Strube P. A comparison of the long-term results of anterior lumbar interbody fusion and total disc arthroplasty: a prospective randomized controlled trial with a mean follow-up of 14 years. Bone Joint J. 2025 Jun 1;107-B(6):639-648.
https://pubmed.ncbi.nlm.nih.gov/40449550/
Arzani A, Verna B, Caffard T, …, Zippelius T, …, Hughes AP. Association between subaxial paraspinal muscle parameters and cervical vertebral bone quality in preoperative patients. J Neurosurg Spine. 2025 Apr 4;42(6):687-696.
https://pubmed.ncbi.nlm.nih.gov/40184677/
Schultz C, Rodewald M, Weidisch A, …, Zippelius T, Popp J. 4D-Spatiotemporal SHG Imaging for the Analysis of Drug-Induced Changes in the Dura Mater. Anal Chem. 2025 Feb 25;97(7):3892-3900.
https://pubmed.ncbi.nlm.nih.gov/39949305/
2024
Caffard T, Chiapparelli E, Arzani A, …, Zippelius T, …, Hughes AP. Diagnosis and evaluation of cervical ossification of the posterior longitudinal ligament on Zero-Echo Time Magnetic Resonance Imaging: an illustrative case series. Eur J Orthop Surg Traumatol. 2024 Nov 21;35(1):9.
https://pubmed.ncbi.nlm.nih.gov/39567399/
Caffard T, Arzani A, Amoroso K, …, Zippelius T, …, Hughes AP. Importance of the lumbar paraspinal muscles on the maintenance of global sagittal alignment after lumbar pedicle subtraction osteotomy. J Neurosurg Spine. 2024 Jun 7;41(3):332-340.
https://pubmed.ncbi.nlm.nih.gov/38848601/
Caffard T, Arzani A, Verna B, …, Zippelius T, …, Hughes AP. Importance of the cervical paraspinal muscles in postoperative patient-reported outcomes and maintenance of sagittal alignment after anterior cervical discectomy and fusion. J Neurosurg Spine. 2024 May 3;41(2):149-158.
https://pubmed.ncbi.nlm.nih.gov/38701526/
Caffard T, Medina SJ, Arzani A, …, Zippelius T, …, Hughes AP. Association patterns between lumbar paraspinal muscles and sagittal malalignment in preoperative patients undergoing lumbar three-column osteotomy. Spine Deform. 2024 May;12(3):801-809.
https://pubmed.ncbi.nlm.nih.gov/38472693/
Caffard T, Arzani A, Verna B, …, Zippelius T, …, Hughes AP. Association Between Cervical Sagittal Alignment and Subaxial Paraspinal Muscle Parameters. Spine (Phila Pa 1976). 2024 May 1;49(9):621-629.
https://pubmed.ncbi.nlm.nih.gov/38098290/
Caffard T, Awan Malik H, Lutz B, …, Zippelius T. Answer to the Letter to the Editor of Tugba Ozudogru Celik concerning „Association between posterior tibial slope and anatomic spinopelvic parameters: a retrospective cross-sectional study“ by Caffard T, et al. Eur Spine J. 2024 Feb;33(2):752-753.
https://pubmed.ncbi.nlm.nih.gov/38057590/
Schönnagel L, Caffard T, Vu-Han TL, …, Zippelius T, …, Hughes AP. Predicting postoperative outcomes in lumbar spinal fusion: development of a machine learning model. Spine J. 2024 Feb;24(2):239-249.
https://pubmed.ncbi.nlm.nih.gov/37866485/
Schönnagel L, Caffard T, Zhu J, …, Zippelius T, …, Hughes AP. Decision-making Algorithm for the Surgical Treatment of Degenerative Lumbar Spondylolisthesis of L4/L5. Spine (Phila Pa 1976). 2024 Feb 15;49(4):261-268.
https://pubmed.ncbi.nlm.nih.gov/37318098/
2023
Caffard T, Arzani A, Verna B, …, Zippelius T, …, Hughes AP. Association between severity of the cervical foraminal stenosis and paraspinal muscle parameters in patients undergoing anterior cervical discectomy and fusion. J Neurosurg Spine. 2023 Dec 22;40(3):274-281.
https://pubmed.ncbi.nlm.nih.gov/38134419/
Lindemann C, Hölzl A, Böhle S, Zippelius T, Strube P. How Does Anxiety and Depression Affect the Outcome after Periradicular Infiltration Therapy? A Retrospective Analysis of Patients Undergoing CT-Guided Single-Level Nerve Root Infiltration Due to Chronic Monoradicular Pain. Diagnostics (Basel). 2023 Sep 8;13(18):2882.
https://pubmed.ncbi.nlm.nih.gov/37761249/
Caffard T, Awan Malik H, Lutz B, …, Zippelius T. Association between posterior tibial slope and anatomic spinopelvic parameters: a retrospective cross-sectional study. Eur Spine J. 2023 Oct;32(10):3616-3623.
https://pubmed.ncbi.nlm.nih.gov/37368018/
Dornacher D, Lutz B, Fuchs M, Zippelius T, Reichel H. Treatment of borderline hip dysplasia with triple pelvic osteotomy: preoperative values of acetabular index and lateral center edge angle can indicate overcorrection. Arch Orthop Trauma Surg. 2023 Oct;143(10):6139-6146.
https://pubmed.ncbi.nlm.nih.gov/37272987/
Lindemann C, Strube P, Fisahn C, Sgroi M, Dornacher D, Zippelius T. Patient-controlled sublingual sufentanil tablet system versus intravenous opioid analgesia for postoperative pain management after lumbar spinal fusion surgery. Eur Spine J. 2023 Jan;32(1):321-328.
https://pubmed.ncbi.nlm.nih.gov/36472663/
Lindemann C, Strube P, Fisahn C, …, Zippelius T. Next Level in Computed Tomography-Guided Periradicular Infiltration Therapy: Same Efficiency with Less Radiation Exposure. World Neurosurg. 2023 Mar;171:e24-e30.
https://pubmed.ncbi.nlm.nih.gov/36334714/
Dornacher D, Lutz B, Fuchs M, Zippelius T, Reichel H. Acetabular deficiency in borderline hip dysplasia is underestimated by lateral center edge angle alone. Arch Orthop Trauma Surg. 2023 Jul;143(7):3937-3944.
https://pubmed.ncbi.nlm.nih.gov/36271941/
2022
Lindemann C, Zippelius T, Hochberger F, Hölzl A, Böhle S, Strube P. Local Infiltrations in Patients with Radiculopathy or Chronic Low Back Pain Due to Segment Degeneration: Only A Diagnostic Value? J Pers Med. 2022 Oct 30;12(11):1791.
https://pubmed.ncbi.nlm.nih.gov/36579536/
Zippelius T, Strube P, Rohe S, …, Böhle S. The Use of Iloprost in the Treatment of Bone Marrow Edema Syndrome of the Proximal Femur: A Review and Meta-Analysis. J Pers Med. 2022 Oct 23;12(11):1757.
https://pubmed.ncbi.nlm.nih.gov/36573724/
Strube P, Lindemann C, Bahrke M, …, Zippelius TK. Improvement of Adolescent Idiopathic Scoliosis Primary Correction by Brace Design Optimization. Children (Basel). 2022 May 3;9(5):656.
https://pubmed.ncbi.nlm.nih.gov/35626833/
Rohe S, Strube P, Hölzl A, Böhle S, Zippelius T, Lindemann C. Cone-Beam Navigation Can Reduce the Radiation Exposure and Save Fusion Length-Dependent Operation Time in Comparison to Conventional Fluoroscopy in Pedicle-Screw-Based Lumbar Interbody Fusion. J Pers Med. 2022 May 1;12(5):736.
https://pubmed.ncbi.nlm.nih.gov/35629158/
Sgroi M, Huzurudin H, Ludwig M, Zippelius T, Reichel H, Kappe T. MRI Allows Accurate Measurement of Glenoid Bone Loss. Clin Orthop Relat Res. 2022 Sep 1;480(9):1731-1742.
https://pubmed.ncbi.nlm.nih.gov/35452020/
Sgroi M, Kranz M, Seitz AM, …, Zippelius T, …, Kappe T. Comparison of Knotless and Knotted Single-Anchor Repair for Ruptures of the Upper Subscapularis Tendon: Outcomes at 2-Year Follow-up. Orthop J Sports Med. 2022 Mar 15;10(3):23259671221083591.
https://pubmed.ncbi.nlm.nih.gov/35309232/
Böhle S, Röhner E, Zippelius T, Jacob B, Matziolis G, Rohe S. Cytotoxic effect of sodium hypochlorite (Lavanox 0.08%) and chlorhexidine gluconate (Irrisept 0.05%) on human osteoblasts. Eur J Orthop Surg Traumatol. 2022 Jan;32(1):81-89.
https://pubmed.ncbi.nlm.nih.gov/33738603/
Maslaris A, Brinkmann O, Lindemann C, …, Zippelius T, …, Bungartz M. Reliability analysis of CT torsion assessment after closed cephalomedullary nailing of trochanteric femoral fractures. A comparison study of six established methods. J Orthop Sci. 2022 Jan;27(1):146-152.
https://pubmed.ncbi.nlm.nih.gov/33309404/
Böhle S, Rohe S, Kirschberg J, …, Zippelius T, …, Röhner E. Poor Outcome of Above-Knee Amputation after Septic Failure of Revision Total Knee Arthroplasty. J Knee Surg. 2022 May;35(6):645-652.
https://pubmed.ncbi.nlm.nih.gov/32906158/
2021
Pumberger M, Palmowski Y, Strube P, …, Zippelius T, Putzier M. Dual-energy X-ray Absorptiometry Does Not Represent Bone Structure in Patients with Osteoporosis: A Comparison of Lumbar Dual-Energy X-Ray Absorptiometry with Vertebral Biopsies. Spine (Phila Pa 1976). 2021 Jul 1;46(13):861-866.
https://pubmed.ncbi.nlm.nih.gov/34100839/
Maslaris A, Bungartz M, Layher F, Zippelius T, Matziolis G, Brinkmann O. Feasibility Analysis of a Novel Method for the Estimation of Local Bone Mechanical Properties: A Preliminary Investigation of Different Pressure Rod Designs on Synthetic Cancellous Bone Models. Arch Bone Jt Surg. 2021 Mar;9(2):203-210.
https://pubmed.ncbi.nlm.nih.gov/34026938/
Brodt S, Jacob B, Nowack D, Zippelius T, Strube P, Matziolis G. An Isoelastic Monoblock Cup Retains More Acetabular and Femoral Bone Than a Modular Press-Fit Cup: A Prospective Randomized Controlled Trial. J Bone Joint Surg Am. 2021 Jun 2;103(11):992-999.
https://pubmed.ncbi.nlm.nih.gov/33617161/
Strube P, Gunold M, Müller T, …, Zippelius T. Influence of curve morphology and location on the efficacy of rigid conservative treatment in patients with adolescent idiopathic scoliosis. Bone Joint J. 2021 Feb;103-B(2):373-381.
https://pubmed.ncbi.nlm.nih.gov/33517722/
Fisahn C, Lindemann C, Burgess B, Strube P, Zippelius T. Lumbar hemivertebra resection in congenital scoliosis utilizing cone-beam navigation: less radiation, more accuracy, proof of concept. Childs Nerv Syst. 2021 Jun;37(6):2081-2086.
https://pubmed.ncbi.nlm.nih.gov/33506302/
Heinrich A, Reinhold M, Güttler FV, …, Zippelius T, Strube P. MRI following scoliosis surgery? An analysis of implant heating, displacement, torque, and susceptibility artifacts. Eur Radiol. 2021 Jun;31(6):4298-4307.
https://pubmed.ncbi.nlm.nih.gov/33277671/
Röhner E, Zippelius T, Böhle S, Rohe S, Matziolis G, Jacob B. Vancomycin is toxic to human chondrocytes in vitro. Arch Orthop Trauma Surg. 2021 Mar;141(3):375-381.
https://pubmed.ncbi.nlm.nih.gov/32236713/
2020
Zippelius T, Bürger J, Schömig F, Putzier M, Matziolis G, Strube P. Clinical presentation and diagnosis of acute postoperative spinal implant infection (PSII). J Spine Surg. 2020 Dec;6(4):765-771.
https://pubmed.ncbi.nlm.nih.gov/33447681/
Brodt S, Matziolis G, Buckwitz B, Zippelius T, Strube P, Roth A. Long-term follow-up of bone remodelling after cementless hip arthroplasty using different stems. Sci Rep. 2020 Jun 23;10(1):10143.
https://pubmed.ncbi.nlm.nih.gov/32576922/
Röhner E, Jacob B, Böhle S, …, Zippelius T. Sodium hypochlorite is more effective than chlorhexidine for eradication of bacterial biofilm of staphylococci and Pseudomonas aeruginosa. Knee Surg Sports Traumatol Arthrosc. 2020 Dec;28(12):3912-3918.
https://pubmed.ncbi.nlm.nih.gov/32034427/
Zippelius T, Strube P, Matziolis G, Röhner E, Böhle S, Brodt S. Cone beam-navigated core decompression of bone marrow edema syndrome. Arch Orthop Trauma Surg. 2020 Nov;140(11):1603-1609.
https://pubmed.ncbi.nlm.nih.gov/31960167/
2019
Jacob B, Kloss N, Böhle S, …, Zippelius T, …, Röhner E. Tranexamic acid is toxic on human chondrocytes, in vitro. J Orthop. 2019 Dec 19;20:1-5.
https://pubmed.ncbi.nlm.nih.gov/32021047/
Zippelius T, Matziolis G, Röhner E, Windisch C, Lindemann C, Strube P. Psychological distress and health-related quality of life in patients with bone marrow edema syndrome. Ann Transl Med. 2019 Oct;7(20):552.
https://pubmed.ncbi.nlm.nih.gov/31807533/
Strube P, Schöpe T, Hölzl A, Brodt S, Matziolis G, Zippelius TK. Influence of Anxiety and Depression, Self-Rated Return-to-Work Problems, and Unemployment on the Outcome of Outpatient Rehabilitation After Shoulder Arthroscopy. Am J Phys Med Rehabil. 2019 Dec;98(12):1118-1124.
https://pubmed.ncbi.nlm.nih.gov/31261254/
Zippelius T, Hoff P, Strube P, …, Röhner E. Effects of iloprost on human mature osteoblasts in vitro. J Back Musculoskelet Rehabil. 2019;32(6):897-903.
https://pubmed.ncbi.nlm.nih.gov/30958330/
Maslaris A, Layher F, Bungartz M, Zippelius T, …, Matziolis G. Sagittal profile has a significant impact on the explantability of well-fixed cemented stems in revision knee arthroplasty: a biomechanical comparison study of five established knee implant models. Arch Orthop Trauma Surg. 2019 Jul;139(7):991-998.
https://pubmed.ncbi.nlm.nih.gov/30927062/
Graul I, Zippelius T, Hölzl A, Strube P. Elongated Conus Medullaris, Sacral Agenesis, and Scoliosis: A Case Report of a Patient with Trisomy 19q and Monosomy 7q. World Neurosurg. 2019 Apr;124:192-196.
https://pubmed.ncbi.nlm.nih.gov/30641238/
Zippelius T, Strube P, Suleymanov F, Putzier M, Hölzl A. Safety and efficacy of an electron beam melting technique-manufactured titanium mesh cage for lumbar interbody fusion. Orthopade. 2019 Feb;48(2):150-156.
https://pubmed.ncbi.nlm.nih.gov/30569206/
Strube P, Putzier M, Siewe J, Eicker SO, Dreimann M, Zippelius T. To fuse or not to fuse: a survey among members of the German Spine Society (DWG) regarding lumbar degenerative spondylolisthesis and spinal stenosis. Arch Orthop Trauma Surg. 2019 May;139(5):613-621.
https://pubmed.ncbi.nlm.nih.gov/30542763/
Röhner E, Benad K, Zippelius T, …, Matziolis G. Good clinical and radiological results of total knee arthroplasty using varus valgus constrained or rotating hinge implants in ligamentous laxity. Knee Surg Sports Traumatol Arthrosc. 2019 May;27(5):1665-1670.
https://pubmed.ncbi.nlm.nih.gov/30456570/
Jacob B, Zippelius T, Kloss N, …, Röhner E. Local Anesthetics’ Toxicity toward Human Cultured Chondrocytes: A Comparative Study between Lidocaine, Bupivacaine, and Ropivacaine. Cartilage. 2019 Jul;10(3):364-369.
https://pubmed.ncbi.nlm.nih.gov/29468902/
2018
Zippelius T, Perka C, Preininger B, Matziolis G, Strube P, Röhner E. Long-term effects of intravenous iloprost therapy in patients with bone marrow oedema of the hip. Acta Orthop Belg. 2018 Jun;84(2):172-178.
https://pubmed.ncbi.nlm.nih.gov/30462600/
Maslaris A, Layher F, Brinkmann O, Bungartz M, Zippelius T, Matziolis G. Cemented conical stems can be removed more easily than cylindrical stems, regardless of cone angle in revision knee arthroplasty. Arch Orthop Trauma Surg. 2018 Dec;138(12):1747-1754.
https://pubmed.ncbi.nlm.nih.gov/30367254/
Zippelius T, Sander K, Layher F, Töpfer J, Matziolis G. Gait Analysis before and after Cycle Training Using a 3D Pedal System. Acta Chir Orthop Traumatol Cech. 2018;85(4):281-284.
https://pubmed.ncbi.nlm.nih.gov/30257760/
Müller C, Zippelius T, Strube P, …, Wagner A. Calcaneal Displacement Osteotomies: Less Soft Tissue Irritation in Lateral Compression Plate than Screws. Acta Chir Orthop Traumatol Cech. 2018;85(1):54-56.
https://pubmed.ncbi.nlm.nih.gov/30257770/
Zippelius T, Matziolis G, Perka C, Putzier M, Strube P, Röhner E. Long-Term Effects of Intravenous Iloprost Therapy in Patients with Bone Marrow Oedema of the Knee Joint. Acta Chir Orthop Traumatol Cech. 2018;85(1):17-21.
https://pubmed.ncbi.nlm.nih.gov/30257764/
Zippelius T, Weschenfelder W, Eicker SO, …, Strube P. Establishing an Interdisciplinary Compulsory Elective Subject ‘Spine’ in the Curriculum of the University Study Course of Human Medicine. Acta Chir Orthop Traumatol Cech. 2018;85(3):165-170.
https://pubmed.ncbi.nlm.nih.gov/30257774/
Strube P, Pumberger M, Sonnow L, Zippelius T, …, Putzier M. Association Between Lumbar Spinal Degeneration and Anatomic Pelvic Parameters. Clin Spine Surg. 2018 Jul;31(6):263-267.
https://pubmed.ncbi.nlm.nih.gov/29863597/
Schiffner R, Lehmann T, Bischoff SJ, Zippelius T, Nistor M, Schmidt M. Pulmonary hemodynamic effects and pulmonary arterial compliance during hypovolemic shock and reinfusion with human relaxin-2 (serelaxin) treatment in a sheep model. Clin Hemorheol Microcirc. 2018;70(3):311-325.
https://pubmed.ncbi.nlm.nih.gov/29710689/
2016
Röhner E, Pfitzner T, Preininger B, Zippelius T, Perka C. Temporary arthrodesis using fixator rods in two-stage revision of septic knee prothesis with severe bone and tissue defects. Knee Surg Sports Traumatol Arthrosc. 2016 Jan;24(1):84-8.
https://pubmed.ncbi.nlm.nih.gov/25246173/
2014
Consmüller T, Rohlmann A, Weinland D, …, Zippelius T, …, Taylor WR. Automatic distinction of upper body motions in the main anatomical planes. Med Eng Phys. 2014 Apr;36(4):516-21.
https://pubmed.ncbi.nlm.nih.gov/24230982/
Röhner E, Zippelius T, Steindl D, Fussi J, Perka C. Effects of intravenous iloprost therapy in patients with bone marrow oedema of the foot and ankle. Eur J Orthop Surg Traumatol. 2014 Dec;24(8):1609-16.
https://pubmed.ncbi.nlm.nih.gov/24048706/
2013
Zippelius T, Hoburg A, Preininger B, …, Röhner E. Effects of indigo carmine on human chondrocytes in vitro. Open Orthop J. 2013;7:8-11.
https://pubmed.ncbi.nlm.nih.gov/23341851/
Alle Veröffentlichungen: Timo Zippelius bei PubMed
https://pubmed.ncbi.nlm.nih.gov/?term=zippelius+t